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Contamination occurs most commonly from liquid chemical contact because liquids can easily spread and penetrate surfaces, allowing hazardous substances to infiltrate materials and environments more thoroughly than other states of matter. Liquid chemicals can soak into soil, permeate through protective equipment, and persist in the environment, leading to a higher probability of exposure and long-term contamination.

While vapor, dust, and gaseous contact can also contribute to contamination, they generally do not pose the same risks of saturation and prolonged exposure as liquid chemicals do. Liquid spills are often the primary concern in hazardous waste operations because they can lead to immediate and widespread environmental impacts, making it crucial for personnel to be trained to handle and respond to these situations effectively.